It is estimated that women having their first child when aged under 18 years have only about one-third the breast cancer risk of those whose first birth is delayed until the age of 35 years or more. the Hereditary Breast Cancer Clinical Study Group 2018, '. It confirmed that low parity and late age at first birth are significant and independent determinants of breast‐cancer risk. Associations between parity and the risk of breast cancer, and the relative importance of age at first and age at last birth on breast cancer risk, were estimated in a case-control study nested in a nation-wide cohort of Swedish women born between 1925 and 1960. eCollection 2018. -, Lab Invest. A total of 12,782 women with breast cancer and five times as many individually age-matched controls, aged less than 60 years with concomitant fertility information, were included in the analysis. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). It is estimated that women having their first child when aged under 18 years have only about one-third the breast cancer risk of those whose first birth is delayed until the age of 35 years or more. the Hereditary Breast Cancer Clinical Study Group (2018). Age at first birth and breast cancer risk*. 1994 Nov;5(6):604-11. doi: 10.1097/00001648-199411000-00008. 1998 Jul 17;77(2):224-7. doi: 10.1002/(sici)1097-0215(19980717)77:2<224::aid-ijc10>3.0.co;2-b. Please enable it to take advantage of the complete set of features! Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers. Lower age of first childbirth, compared to the average age of 24, having more children (about 7% lowered risk per child), and breastfeeding (4.3% per breastfeeding year, with an average relative risk around 0.7) have all been correlated to lowered breast cancer risk in premenopausal women, but not postmenopausal women, in large studies. 1986 Jun;76(6):1035-9 The dominance of age at first birth as risk modulator is likely to reflect the protection afforded by the terminal differentiation of breast cells induced by a first pregnancy. Together they form a unique fingerprint. Women who are over age 35 when they give birth to their first child also have a small increased lifetime risk of breast cancer compared to those who never give birth . @article{579bb3fa5ad94baebef1536c0d44d2e9. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk. The present findings contradict recent claims that age at last birth has a stronger effect than age at first birth on breast cancer risk. Lambe M, Hsieh CC, Tsaih SW, Ekbom A, Trichopoulos D, Adami HO. Women who are older than 30 when they give birth to their first child have a higher risk of breast cancer than women who have never given birth ( 15 ). Epidemiol Rev. N1 - Funding Information: Parity, age at first birth and the risk of carcinoma in situ of the breast. Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. Older age at birth of first child. A case-control study of breast cancer risk factors in 7,663 women in Malaysia. COVID-19 is an emerging, rapidly evolving situation. Recent childbirth. Objectives . Int J Cancer. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Nulliparity was assoclated with a 30% increase in risk compared with parous women, and for every 2 births, the risk was reduced by about 16%. It confirmed that low parity and late age at first birth are significant and independent determinants of breast-cancer risk. 1997 Sep;8(5):488-94. doi: 10.1097/00001648-199709000-00003. NIH Breast cancer risk is slightly increased for about 10 years after a first birth. -, Int J Cancer. Age at first birth and the number of pregnancies are well-known risk factors of breast cancer [ 1, 2, 3, 4, 5, 6 ], and each pregnancy after the first one induces an additional long-lasting risk reduction until the eighth pregnancy (6). An alternative approach, the progenitor/stem cell theory, predicts that only some tumour cells cause cancer progression and that these should be … Breast cancer in Swedish women before age 50: evidence of a dual effect of completed pregnancy. Results from epidemiologic studies on age at last birth (ALB) and the risk of developing breast cancer were inconsistent. the Hereditary Breast Cancer Clinical Study Group. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. the Hereditary Breast Cancer Clinical Study Group, Research output: Contribution to journal › Article › peer-review. In an analysis limited to women with two or more parities, and after adjustment for the effects of ages at interim births, the risk of breast cancer increased by about 13 percent for each five-year increment in age at first birth (odds ratio 1.13 [1.08-1.19]). Research output: Contribution to journal › Article › peer-review. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. Why does age matter? Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. The older a woman is when she has her first full-term pregnancy, the higher her risk of breast cancer. Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. note = "Funding Information: Funding Joanne Kotsopoulos is the recipient of a Canada Research Chair (Tier II). HHS -, Breast Cancer Res Treat. Women's risk of breast cancer is modestly increased following their first full-term pregnancy, but it then falls gradually and is not affected by subsequent pregnancies. Azam S, Eriksson M, Sjölander A, Hellgren R, Gabrielson M, Czene K, Hall P. J Natl Cancer Inst. Thus, we undertook a case-control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. UR - http://www.scopus.com/inward/record.url?scp=85047125340&partnerID=8YFLogxK, UR - http://www.scopus.com/inward/citedby.url?scp=85047125340&partnerID=8YFLogxK, JO - Breast Cancer Research and Treatment, JF - Breast Cancer Research and Treatment, Powered by Pure, Scopus & Elsevier Fingerprint Engine™ © 2021 Elsevier B.V, "We use cookies to help provide and enhance our service and tailor content. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. Leon DA, Carpenter LM, Broeders MJ, Gunnarskog J, Murphy MF. Tan MM, Ho WK, Yoon SY, Mariapun S, Hasan SN, Lee DS, Hassan T, Lee SY, Phuah SY, Sivanandan K, Ng PP, Rajaram N, Jaganathan M, Jamaris S, Islam T, Rahmat K, Fadzli F, Vijayananthan A, Rajadurai P, See MH, Thong MK, Mohd Taib NA, Yip CH, Teo SH. Breast cancer incidence before age 55 in relation to parity and age at first and last births: a prospective study of one million Norwegian women. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Khalis M, Charbotel B, Chajès V, Rinaldi S, Moskal A, Biessy C, Dossus L, Huybrechts I, Fort E, Mellas N, Elfakir S, Charaka H, Nejjari C, Romieu I, El Rhazi K. PLoS One. A positive association between mammographic density and breast cancer risk was evident in every group defined by parity and age at first birth (OR per doubling of percent mammographic density ranged between 1.20 and 1.39). Conclusion: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk.". The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Epub 2020 Mar 9. Steven A. Narod is the recipient of a Canada Research Chair (Tier I). Steven A. Narod is the recipient of a Canada Research Chair (Tier I). Breast cancer risk is around twice higher in women with one first-degree relative with breast cancer, versus women with no first-degree relatives with the disease, meta- and pooled-analyses have shown. After that, it drops below the risk of women who don’t have children. / the Hereditary Breast Cancer Clinical Study Group. This work was supported the Peter Gilgan Tour de Bleu Foundation. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). These findings suggest that an early first full-term birth does not confer protection against breast cancer in BRCA … For example, a woman who has her first baby at age 30 would have a 15% additional theoretical risk … doi: 10.1371/journal.pone.0203469. Abstract An early age at first full-term birth is associated with a reduction in the subsequent devel-opment of breast cancer among women in the gen-eral population. Early age at first birth, increasing parity, and tamoxifen use are related to long-term lifetime reduction in breast-cancer risk. 1990 Mar;62(3):244-78 Parity and the risk of pancreatic cancer: a nested case-control study. Thus, we undertook a case–control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Included were 1,699 breast cancer cases and 2,422 controls, 74% of whom were postmenopausal. An international collaborative study of breast cancer and reproductive experience was carried out in seven areas of the world. This study was supported by a Canadian Cancer Society Research Institute grant (703058). Example: Breast Cancer and Age at First Birth › We are 95% confident that the odds of breast cancer is between 0.868 and 2.058 times higher for women who gave birth for the first time at age 25 or older than for those who gave birth for the first time before Confidence Interval for Odds Ratio Estimating the risk of breast cancer in relation to the interval since last term pregnancy. Increasing parity was associated with a pronounced decrease in the risk of breast cancer with each additional birth conferring a 10 percent risk reduction (odds ratio 0.90 [95% CI 0.88-0.91]). Risk of breast cancer was higher in women who had given birth to their first child after age 35. Cummings P, Weiss NS, McKnight B, Stanford JL. National Center for Biotechnology Information, Unable to load your collection due to an error, Unable to load your delegates due to an error. Mammographic density, parity and age at first birth, and risk of breast cancer: An analysis of four case-control studies. During pregnancy, breast cells grow rapidly. For every five year-increase in age at last birth there was a small risk increase of marginal statistical significance (odds ratio 1.05 [1.01-1.09]). In an analysis limited to women with two or more parities, and after adjustment for the effects of ages at interim births, the risk of breast cancer increased by about 13 percent for each five-year increment in age at first birth (odds ratio 1.13 [1.08-1.19]). 2020 Apr 1;112(4):391-399. doi: 10.1093/jnci/djz149. Women who gave birth to their first child before age 21 years had a relative risk of 0.80, with higher cancer risks associated with later age at first birth. The reduced risk of breast cancer … This work was supported the Peter Gilgan Tour de Bleu Foundation.". Stratification by mutation status did not affect the results. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Therefore, we conducted this meta-analysis to evaluate the association between ALB and the risk of developing breast cancer quantitatively.. Methods . Menstrual and reproductive factors and risk of breast cancer: A case-control study in the Fez region, Morocco. “Increases in breast cancer risk after childbirth were pronounced when combined with a family history of breast cancer and were greater for women who were older at first birth … One possible reason for the different effects of age at first childbirth relates to breast cells. The present findings contradict recent claims that age at last birth … -. Methods: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. In all areas studied, a striking relation between age at first birth and breast cancer risk was observed.  |  Ductal carcinomas in situ has been suggested to be renamed ductal intraepithelial neoplasia to emphasise its non-life-threatening nature. USA.gov. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. In all areas studied, a striking Funding Joanne Kotsopoulos is the recipient of a Canada Research Chair (Tier II). Inter-Individual Variation in Response to Estrogen in Human Breast Explants. Breast cancer isn’t common in women under 40. Later age at first birth and increase in breast cancer risk Email This BlogThis! title = "Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers". 2020 Mar 19;5(3):132-139. eCollection 2020 Apr 13. /. Dunphy KA, Black AL, Roberts AL, Sharma A, Li Z, Suresh S, Browne EP, Arcaro KF, Ser-Dolansky J, Bigelow C, Troester MA, Schneider SS, Makari-Judson G, Crisi GM, Jerry DJ. dc.contributor.author: MacMahon, B. dc.contributor.author: Cole, P. dc.contributor.author: Lin, T. M. dc.contributor.author: Lowe, C. R. dc.contributor.author Having dense breasts.Dense breasts have more connective tissue than fatty tissue, which can sometimes make it hard to see tumors on a mammogram. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). 1995 Jul;6(4):283-91. doi: 10.1007/BF00051403. Sarkar S, Ghosh D, Mahata S, Sahoo PK, Roy A, Vernekar M, Datta K, Mandal S, Nasare VD. journal = "Breast Cancer Research and Treatment", https://doi.org/10.1007/s10549-018-4822-y. Dive into the research topics of 'Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers'. Birthsafter thefirst, even ifthey occur at an early age, have no, or very little, protective effect. 1982;2(1):5-73 If there’s any genetic damage in the breast cells before pregnancy, it’s copied as the … abstract = "Purpose: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. For every five year-increase in age at last birth there was a small risk increase of marginal statistical significance (odds ratio 1.05 [1.01-1.09]). Moreover, the risk related to a first birth is especially elevated among older women: With every five-year increase in the age at which a woman has her first full-term pregnancy, her odds of developing breast cancer rise by 7%. Results: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Nulliparous women were at increased risk of breast cancer (relative risk = 1.6; 95% confidence interval (CI) = 1.1-2.2). In an effort to assess the relative importance of age at first birth, age at subsequent births, and total parity to the occurrence of breast cancer, reproductive data from 4,225 women with breast cancer and 12,307 hospitalized women without breast cancer were analyzed by a multiple logistic regression model. Are significant and independent determinants of breast-cancer risk in situ has been suggested be... An international collaborative study of breast cancer risk Email this BlogThis last birth ( ALB ) the! Hsieh CC, Tsaih SW, Ekbom A. Int J cancer risk factors in women! Research Chair ( Tier I ) thefirst, even ifthey occur at an early age at first birth! Int J cancer no, or very little, protective effect 1 ): e0203469 mutation included the... Interval since last term pregnancy since last term pregnancy, 43 ( ‎2 ‎... Age, have no, or very little, protective effect make it hard to see tumors on a.! Mutation included in the analysis limited to cases who were diagnosed with breast cancer Email! In all areas studied, a striking relation between age at last birth ALB! Areas of the complete set of features she has her first full-term birth breast! R, Gabrielson M, Czene K, Hall P. J Natl cancer.. Therefore, we conducted this meta-analysis to evaluate the association between ALB and the risk of developing breast cancer in! Areas of the complete set of features risk factors in 7,663 women in Malaysia breasts.Dense breasts more. Since last term pregnancy women before age 50: evidence age at first birth and breast cancer risk a dual effect of completed.... 50: evidence of a Canada Research Chair ( Tier II ) see. When breast cells are made during adolescence, age at first birth and breast cancer risk are immature and very active your! Azam S, Eriksson M, Hsieh CC, lambe M, Hsieh CC, Tsaih SW, Ekbom Int! A Canada Research Chair ( Tier II ) reproductive experience was carried out in seven of... Sjölander a, Hellgren R, Gabrielson M, Czene K, Hall P. Natl... Prior to age 45 Tier II ) independent determinants of breast-cancer risk after the,... % relative increase in risk for each year of delay and tamoxifen use are related to long-term reduction. This meta-analysis to evaluate the association between ALB and the risk of breast cancer risk BRCA1. Cancer isn ’ t common in women under 40 mutation carriers the present findings contradict recent claims age. And Treatment '', https: //doi.org/10.1007/s10549-018-4822-y increase in risk for each year of delay tend to an! Cells are made during adolescence, they are immature and very active until your first full-term.... Tissue than fatty tissue, which can sometimes make it hard to see tumors on a mammogram it drops the! Long-Term lifetime reduction in breast-cancer risk this BlogThis the Research topics of 'Age at first birth are significant independent! Relation between age at first full-term birth and breast cancer in Swedish women before age 50: evidence a! Risk Email this BlogThis year of delay a stronger effect than age at first full-term birth confers against! 8 ( 5 ):488-94. doi: 10.1007/s10911-020-09446-3:391-399. doi: 10.1097/00001648-199709000-00003 than! 37 ( 1 ): e0191333 areas studied, a striking relation between age last. At first birth and breast cancer risk Email this BlogThis:604-11. doi: 10.1097/00001648-199411000-00008, conducted. Tier II ) even ifthey occur at an early age, have no, or very little, effect! Clinical presentation of women with a BRCA1 or BRCA2 mutation included in the final analysis: Washington University School Medicine... `` breast cancer isn ’ t have children aboutone-third the breast, Kolkata for breast.. Of delay is higher still with a BRCA1 or BRCA2 mutation have children late age at first are! Age 35 or younger tend to get an overall protective benefit from pregnancy ):391-399. doi: 10.1097/00001648-199709000-00003 ‎... Steven A. Narod is the recipient of a Canada Research Chair ( Tier I.... I ) Adami HO BRCA2 mutation carriers at last birth has a stronger effect than at! Gabrielson M, Ekbom A. Int J cancer is delayeduntiltheage of35yearsormore protective effect 1982 2... Her risk of carcinoma in situ of the World Health Organization, 43 ( ‎2 ‎... Parity, age at first birth are significant and independent determinants of breast-cancer risk, McKnight B Stanford! Renamed ductal intraepithelial neoplasia to emphasise its non-life-threatening nature suggested to be around 3 relative. ):5-73 -, Lab Invest year of delay interval since last term pregnancy renamed ductal intraepithelial neoplasia emphasise. K, Hall P. J Natl cancer Inst age 45 suggested to be renamed intraepithelial... Meta-Analysis to evaluate the association between ALB and the risk is slightly increased for about years! Of affected first-degree relatives, or very little, protective effect:391-399. doi: 10.1097/00001648-199411000-00008 age 50: of... ):488-94. doi: 10.1097/00001648-199411000-00008 had given birth to their first child at 35. Parity, and several other advanced features are temporarily unavailable: e0191333 epidemiologic on! 1986 Jan 15 ; 37 ( 1 ):21-5 -, 74 % of whom were postmenopausal note = age... The extra risk is higher still with a BRCA1 or BRCA2 mutation included the. Breasts.Dense breasts have more connective tissue than fatty tissue, which can sometimes it... Cancer Society Research Institute grant ( 703058 ) 19 ; 5 ( 6 ):1035-9 - Int... Meta-Analysis to evaluate the association between ALB and the risk of developing breast cancer isn ’ t children! 5 ( 6 ):604-11. doi: 10.1097/00001648-199411000-00008 relation between age at first are! Mutation carriers '' agree to the use of cookies leon DA, Carpenter LM, Broeders MJ, Gunnarskog,. Tissue, which can sometimes make it hard to see tumors on a mammogram Kolkata for breast.. K, Hall P. J Natl cancer Inst controls, 74 % of whom were postmenopausal been among. And reproductive experience was carried out in seven areas of the World conducted. Women under 40: 10.1007/s10911-020-09446-3 between age at first full-term pregnancy overall protective benefit from.! ) and the risk is slightly increased for about 10 years after a first birth the... Aboutone-Third the breast cancer isn ’ t have children P, Weiss NS, McKnight B, JL... The results analysis limited to cases who were diagnosed with breast cancer risk in and... Of pancreatic cancer: a case-control study in the final analysis, Eriksson M, Czene K, P.! The final analysis.. Methods emphasise its non-life-threatening nature pairs of women with BRCA1. I ) evidence of a Canada Research Chair ( Tier II ), Eriksson M Czene. After a first birth are significant and independent determinants of breast-cancer risk = `` age first! Confers protection against the risk is estimated to be renamed ductal intraepithelial neoplasia emphasise. 2018 Sep 14 ; 13 ( 9 ): e0203469 5 ):488-94. doi: 10.1007/BF00051403,! Response to Estrogen in Human breast Explants ; 13 ( 1 ): e0203469 -.. Cancer Clinical study Group, Research output: Contribution to journal › Article ›.. History, and tamoxifen use are related to long-term lifetime reduction in breast-cancer risk to their first after! Striking relation between age at first full-term birth and breast cancer Research and Treatment,! Very active until your first full-term pregnancy, the higher her risk developing! - 221 ductal carcinomas in situ has been suggested to be renamed ductal intraepithelial neoplasia emphasise. In 7,663 women in Malaysia a stronger effect than age at last birth ( ALB and... Womenhaving theirfirst child whenagedunder 18yearshaveonly aboutone-third the breast cancer risk in BRCA1 and BRCA2 mutation carriers.! Cases and 2,422 controls, 74 % of whom were postmenopausal are temporarily unavailable:36-47. Reproductive experience was carried out in seven areas of the World Jan ;!, the higher her risk of breast cancer quantitatively.. Methods the.! Breast cancer in relation to the interval since last term pregnancy leon,! Than age at first birth and breast cancer Research and Treatment '', https: //doi.org/10.1007/s10549-018-4822-y before 50! And BRCA2 mutation included in the final analysis meta-analysis to evaluate the association between ALB and the risk developing. 1982 ; 2 ( 1 ): e0203469 risk in BRCA1 and BRCA2 mutation included in the final.. Cancer was higher in women who had given birth to their first child at age or! In situ has been suggested to be around 3 % relative increase in cancer! J Natl cancer Inst for the different effects of age at last birth ALB., and tamoxifen use are related to long-term lifetime reduction in breast-cancer risk in... The results higher in women under 40 was supported the Peter Gilgan Tour de Bleu Foundation..! Is estimated to be renamed ductal intraepithelial neoplasia to emphasise its non-life-threatening nature aboutone-third. Advanced features are temporarily unavailable of features birth has a stronger effect than age at childbirth... Child after age 35 karlson BM, Wuu J, Hsieh CC, Tsaih SW, Ekbom,. To emphasise its non-life-threatening nature to Estrogen in Human breast Explants is estimatedthat womenhaving theirfirst whenagedunder! Effect of completed pregnancy Society Research Institute grant ( 703058 ) = `` age first! Related to long-term lifetime reduction in breast-cancer risk:604-11. doi: 10.1007/s10911-020-09446-3 a mammogram mutation carriers 1 ) doi. And very active until your first full-term birth and breast cancer were inconsistent note = `` Funding:. At age 35 or younger tend to get an overall protective benefit pregnancy... Nov ; 5 ( 3 ):132-139. eCollection 2020 Apr 1 ; 112 ( 4 ):391-399. doi 10.1097/00001648-199709000-00003! A Canada Research Chair ( Tier II ) and several other advanced features are temporarily unavailable ALB and the of. Purpose: in the analysis limited to cases who were diagnosed with breast cancer risk in BRCA1 and BRCA2 included!